Sorry about the late response. If she has not gone into heat yet, then you can spay her now. But if you want to wait after her first heat then wait about 3 months after her heat before spaying her. There is really nothing you need to do for her. You might want to get some diapers for her to wear, but sometimes they are hard to keep on her. If no diapers then you will want to keep her crated most of the time, or put her in a room without carpet so it will be easier to clean. I would keep the males away from her, even though they are neutered, just to keep them off her. If you have any other questions about this just let us know. I hope this helps.